When Hyaluronic Filling Spheres are applied to the surface of the skin, they enter wrinkles and lines and penetrate the upper layers of the epidermis. The Hyaluronic Filling Spheres rehydrate by taking up water evaporating from the skin. The depth of the wrinkles and lines are rapidly reduced. Clinical test results show a decrease of 7.5% in forehead expression wrinkles after 1 hour and 12% after 6 hours.They Hyaluronic Filling Spheres are composed of a mixture of high and low molecular weight hyaluronic acids, perfectly accepted by sking tissue. When applied they easily lodge in skin tissue depressions (wrinkles) where they progressively, but rapidly rehydrate the skin by taking up water that evaporates via the well known process of Trans-epidermal Water Loss. This physical action leads to a volume change of Hyaluronic Filling Spheres in the epidermis that almost immediately smooths deep wrinkles, while at the same time increasing the long-term hydration of the upper layers of the epidermis